Endocrine Abstracts

Methods: A prospective study in 35 patients hospitalized for AKI for two consecutive years was carried out. TFT (serum thyrotropin, TSH; free thyroxine, FT4; and total triiodothyronine, T3 concentrations) were measured in each patient on three occasions: at admission, at hospital discharge and at their first outpatient visit.Results: Total prevalence of alterations in TFT was 82.9% (n=29). Of those, euthyroid sick syndrome (E...

Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key regulatory action remain largely unexplored. We report herein that the microRNA, miR-30, with three binding sites in a highly conserved region of its 3’-untranslated region (UTR), operates as repressor of Mkrn3 to control pube...